Endoplasmic reticulum targeted chemotherapeutics: the remarkable photo-cytotoxicity of an oxovanadium(IV) vitamin-B6 complex in visible light
| Data(s) |
2014
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|---|---|
| Resumo |
An oxovanadium(IV) vitamin-B6 Schiff base complex, viz. VO(HL)( acdppz)] Cl, having (acridinyl) dipyridophenazine (acdppz) shows specific localization to endoplasmic reticulum (ER) and remarkable apoptotic photocytotoxicity in visible light (400-700 nm) in HeLa and MCF-7 cancer cells (IC50 < 0.6 mu M) while being non-toxic in the dark and to MCF-10A normal cells (IC50 > 40 mu M). |
| Formato |
application/pdf |
| Identificador |
http://eprints.iisc.ernet.in/49229/1/che_com-50-42_5590_2014.pdf Banerjee, Samya and Dixit, Akanksha and Shridharan, Radhika N and Karande, Anjali A and Chakravarty, Akhil R (2014) Endoplasmic reticulum targeted chemotherapeutics: the remarkable photo-cytotoxicity of an oxovanadium(IV) vitamin-B6 complex in visible light. In: CHEMICAL COMMUNICATIONS, 50 (42). pp. 5590-5592. |
| Publicador |
ROYAL SOC CHEMISTRY |
| Relação |
http://dx.doi.org/10.1039/c4cc02093f http://eprints.iisc.ernet.in/49229/ |
| Palavras-Chave | #Biochemistry #Inorganic & Physical Chemistry |
| Tipo |
Journal Article PeerReviewed |
