Intracellular delivery of doxorubicin encapsulated in novel pH-responsive chitosan/heparin nanocapsules
Data(s) |
2013
|
---|---|
Resumo |
A novel polyelectrolyte nanocapsule system composed of biopolymers, chitosan and heparin has been fabricated by the layer-by-layer technique on silica nanoparticles followed by dissolution of the silica core. The nanocapsules were of the size range 200 +/- 20 nm and loaded with the positively charged anticancer drug doxorubicin with an efficiency of 89%. The loading of the drug into the capsule happens by virtue of the pH-responsive property of the capsule wall, which is determined by the pKa of the polyelectrolytes. As the pH is varied, about 64% of the drug is released in acidic pH while 77% is released in neutral pH. The biocompatibility, efficiency of drug loading, and enhanced bioavailability of the capsule system was confirmed by MTT assay and in vivo biodistribution studies. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/46672/1/Int_Jou_Nan_8_267_2013.pdf Thomas, Midhun B and Radhakrishnan, Krishna and Gnanadhas, Divya P and Chakravortty, Dipshikha and Raichur, Ashok M (2013) Intracellular delivery of doxorubicin encapsulated in novel pH-responsive chitosan/heparin nanocapsules. In: International Journal of Nanomedicine, 8 . pp. 267-273. |
Publicador |
Dove Medical Press Ltd |
Relação |
http://dx.doi.org/10.2147/IJN.S37737 http://eprints.iisc.ernet.in/46672/ |
Palavras-Chave | #Microbiology & Cell Biology #Materials Engineering (formerly Metallurgy) |
Tipo |
Journal Article PeerReviewed |