Ribosome-RNA interaction: a potential target for developing antiviral against hepatitis C virus


Autoria(s): Ray, Upasana; Ray, Partho Sarothi; Das, Saumitra
Data(s)

10/02/2012

Resumo

Hepatitis C virus (HCV), a member of Flaviviridae, encoding a positive-sense single-stranded RNA translates by cap-independent mechanism using the internal ribosome entry site (IRES) present in the 5' UTR of the virus. The IRES has complex stem loop structures and is capable of recruiting the 40S ribosomal subunit in a factor-independent fashion. As the IRES sequence is highly conserved throughout the HCV genotypes and the translation is the first obligatory step of the HCV life cycle, the IRE'S-mediated translation, or more specifically, the ribosome HCV RNA interaction is an attractive target to design effective antivirals. This article will focus on the mechanism of the HCV IRES translation and the various ways in which the interaction of ribosome and IRES has been targeted.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/44263/1/

Ray, Upasana and Ray, Partho Sarothi and Das, Saumitra (2012) Ribosome-RNA interaction: a potential target for developing antiviral against hepatitis C virus. In: Current Science (Bangalore), 102 (3). pp. 405-412.

Publicador

Indian Academy of Sciences

Relação

http://cs-test.ias.ac.in/cs/php/toc.php?vol=102&issue=03

http://eprints.iisc.ernet.in/44263/

Palavras-Chave #Microbiology & Cell Biology
Tipo

Journal Article

PeerReviewed