Application of microwave heating technique for rapid synthesis of ?,?-unsaturated esters
Data(s) |
06/02/1995
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Resumo |
The use of microwave heating technique for the acceleration of ortho ester Claisen rearrangement (a three step transformation) is described. Irradiation of a DMF solution of the allyl alcohol 5, triethyl orthoacetate and propionic acid (catalytic) in an Erlenmeyer flask for 10 minutes in a microwave oven generated the ester 8 in 83% yield. Analogously, ortho ester Claisen rearrangement of a variety of allyl and propargyl alcohols (9, 12-22) were achieved. The formation of the diester 10 from 2-butyne-1,4-diol (9) via the ortho ester Claisen rearrangement of two allyl alcohol moieties (involving sh steps) in 15 minutes, demonstrates the versatility of the microwave heating technique. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/36926/1/Microwave.pdf Srikrishna, Adusumilli and Sankuratri, Nagaraju and Kondaiah, Paturu (1995) Application of microwave heating technique for rapid synthesis of ?,?-unsaturated esters. In: Tetrahedron, 51 (6). pp. 1809-1816. |
Publicador |
Elsevier Science |
Relação |
http://dx.doi.org/10.1016/0040-4020(94)01058-8 http://eprints.iisc.ernet.in/36926/ |
Palavras-Chave | #Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME) #Organic Chemistry |
Tipo |
Journal Article PeerReviewed |