A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor protein
Data(s) |
15/07/1979
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Resumo |
The structure and properties of the double-helical form of the alternating copolymer poly(dA-dT) are considered. Different lines of evidence are interpreted in terms of a structure in which every second phosphate-diester linkage has a conformation different from that of the normal B form. A rationale for this “alternating-B” structure is given which provides an explanation for the effects of chemical modifications of the T residues on the binding of the poly(dA-dT)· poly(dA-dT) to the lac repressor of Escherichia coli. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/34394/1/Hypothesis.pdf Klug, A and Jack, A and Viswamitra, MA and Kennard, Olga and Shakked, Z and Steitz, TA (1979) A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor protein. In: Journal of Molecular Biology, 131 (4). pp. 669-680. |
Publicador |
Elsevier Science |
Relação |
http://dx.doi.org/10.1016/0022-2836(79)90196-7 http://eprints.iisc.ernet.in/34394/ |
Palavras-Chave | #Others #Physics |
Tipo |
Journal Article PeerReviewed |