Estradiol - 17β induces polyaromatic hydrocarbon-inducible cytochrome P-450 in chicken liver
Data(s) |
29/03/1991
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Resumo |
A cDNA clone has been isolated from a chicken liver library prepared against messenger RNA isolated after chronic estradiol-17β treatment. The clone, pP-450 IA - 61, has an insert of 900nt and the sequence shows high homology to CYPIA2 subfamily from four other species. A single injection of estradiol-17β to immature chicken results in a striking induction of mRNA hybridizing to labeled pP-450IA - 61. The probe also hybridizes to mRNA induced by 3 — methylcholanthrene in chicken. These results offer direct proof for the similarity in the mode of action at the transcriptional level of polyaromatic hydrocarbons and estrogenic compounds. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/33770/1/ESTRADIOL_-_17B_INDUCES_POLYAROMA.pdf Murti, Ramana J and Adiga, PR and Padmanaban, G (1991) Estradiol - 17β induces polyaromatic hydrocarbon-inducible cytochrome P-450 in chicken liver. In: Biochemical and Biophysical Research Communications, 175 (3). 928-935 . |
Publicador |
Elsevier science |
Relação |
http://dx.doi.org/10.1016/0006-291X(91)91654-U http://eprints.iisc.ernet.in/33770/ |
Palavras-Chave | #Biochemistry |
Tipo |
Journal Article PeerReviewed |