An association model for the solubilities of pharmaceuticals in supercritical carbon dioxide
Data(s) |
10/08/2010
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Resumo |
The equilibrium solubility of a pharmaceutical compound. 1,5-dimethy1-2-phenyl-4-propan-2-ylpyrazol-3-one (propyphenazone, isopropylantipyrine) in supercritical carbon dioxide (SCCO2) was experimentally determined by a saturation method at 308, 318 and 328 K. over the pressure range of 9.0-19.0 MPa. The solubility data satisfied the self-consistency test, proposed by Mendez-Santiago and Teja. A new association model was derived to correlate the solubilities of pharmaceutical compounds in SCCO2. Solubility data from 54 different pharmaceutical compounds including steroids, antibiotics, anti-inflammatory, antioxidants, statins and specific functional drugs were collected from literature. The model successfully correlated the experimental results for the solubilities of all these compounds in SCCO2 within 12% AARD. (C) 2010 Elsevier B.V. All rights reserved. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/32241/1/acta.pdf Ch, Rajasekhar and Madras, Giridhar (2010) An association model for the solubilities of pharmaceuticals in supercritical carbon dioxide. In: Thermochimica Acta, 507-08 . pp. 99-105. |
Publicador |
Elsevier Science |
Relação |
http://dx.doi.org/10.1016/j.tca.2010.05.006 http://eprints.iisc.ernet.in/32241/ |
Palavras-Chave | #Chemical Engineering |
Tipo |
Journal Article PeerReviewed |