Aggregation studies in crystals of apolar helical peptides: Boc-Aib-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-OMe
Data(s) |
01/12/1988
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Resumo |
In the crystal, the backbone of Boc-(Aib-Val-Ala-Leu)2-Aib-OMe adopts a helical form with four alpha-type hydrogen bonds in the middle, flanked by 3(10)-type hydrogen bonds at either end. The helical molecules stack in columns with head-to-tail hydrogen bonds, either directly between NH and CO, or bridged by solvent molecules. The packing of the helices is parallel, even in space group P2(1). Cell parameters are a = 9.837(2) A, b = 15.565(3) A, c = 20.087(5) A, beta = 96.42(2) degrees, dcalc = 1.091 g/cm3 for C46H83N9O12.1.5H2O.0.67CH3OH. There appears to be some hydration of the backbone in this apolar helix. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/27231/1/4.pdf Karle, IL and Flippen-Anderson, JL and Uma, K and Balaram, Padmanabhan (1988) Aggregation studies in crystals of apolar helical peptides: Boc-Aib-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-OMe. In: International Journal of Peptide & Protein Research Int J Pept Protein Res, 32 (6). pp. 536-543. |
Publicador |
National Center for Biotechnology Information |
Relação |
http://www.ncbi.nlm.nih.gov/pubmed/3246478 http://eprints.iisc.ernet.in/27231/ |
Palavras-Chave | #Molecular Biophysics Unit |
Tipo |
Journal Article PeerReviewed |