Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis
Data(s) |
01/09/2015
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Resumo |
There has been significant progress in our understanding of the pathogenesis of AS. The advent of genome-wide association studies has increased the known loci associated with AS to more than 40. The endoplasmic reticulum resident aminopeptidases (ERAP) 1 and 2 were identified in this manner and are of particular interest. There appears to be a genetic as well as a functional interaction of ERAP1 and 2 with HLA-B27 based on the known functions of these molecules. Recent studies on the structure, immunological effects and the peptide-trimming properties of ERAP 1 and 2 have helped to provide insight into their pathogenic potential in AS. In this review, we explore the role of ERAP 1 and 2 in the pathogenesis of AS. © The Author 2015. |
Identificador | |
Publicador |
Oxford University Press |
Relação |
DOI:10.1093/rheumatology/kev218 Kenna, Tony J., Robinson, Philip C., & Haroon, Nigil (2015) Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis. Rheumatology, 54(9), pp. 1549-1556. |
Direitos |
Copyright 2015 The Authors |
Fonte |
Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #Aminopeptidase #Endoplasmic reticulum #Endoplasmic reticulum resident aminopeptidase 1 #Endoplasmic reticulum resident aminopeptidase 2 #Misfolding #NK cell #Peptide #T cell response #Unfolded protein response #endoplasmic reticulum aminopeptidase 1 #endoplasmic reticulum aminopeptidase 2 #HLA B27 antigen #unclassified drug #ankylosing spondylitis #balancing selection #cell surface #dendritic cell #disease association #gene frequency #gene interaction #genetic association #haplotype #human #major histocompatibility complex #priority journal #Review #single nucleotide polymorphism |
Tipo |
Journal Article |