Use of norethisterone and estradiol in mini doses as a contraceptive in the male : Efficacy studies in the adult male bonnet monkey (Macaca radiata)


Autoria(s): Shetty, G; Krishnamurthy, H; Krishnamurthy, HN; Ramachandra, SG; Moudgal, NR
Data(s)

01/10/1997

Resumo

Administration of norethisterone (NET) or NET + estradiol benzoate using an Alzet minipump or as once-a-month intramuscular injection of their depot forms, NET-enanthate (NET-EN) and estradiol valerate (E-val), resulted in azoospermia in all monkeys (n = 13) within 60 to 150 days of treatment. Although addition of depot form of testosterone (T, 20 mg/month) to the regimen restored the behavioral response typical of a normal male, it did not reverse the azoospermic state. Serum T (heightened nocturnal) levels were significantly reduced (> 85%, p < 0.001) in all the treated groups. Evidence for blockade in spermatogenesis following treatment was obtained by DNA flow cytometry. Following withdrawal of treatment, the T level was restored to normalcy within 15 days but 120 days more were required for the animals to exhibit normal sperm counts. In conclusion, the efficacy of once-a-month injection of relatively low doses of NET-EN + E-Val to bring about azoospermia in monkeys, in a relatively short time, has been demonstrated. As the results are uniform and reproducible, it appears desirable that this steroid regimen be tested in man for its contraceptive efficacy.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/24705/1/8.pdf

Shetty, G and Krishnamurthy, H and Krishnamurthy, HN and Ramachandra, SG and Moudgal, NR (1997) Use of norethisterone and estradiol in mini doses as a contraceptive in the male : Efficacy studies in the adult male bonnet monkey (Macaca radiata). In: Contraception, 56 (4). pp. 257-265.

Publicador

Elsevier Science

Relação

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T5P-3S12KT5-9&_user=512776&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000025298&_version=1&_urlVersion=0&_userid=512776&md5=8313c7b7f814d504c9ff977a74bf9c06

http://eprints.iisc.ernet.in/24705/

Palavras-Chave #Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Tipo

Journal Article

PeerReviewed