Effect of some "strong" excitants of central neurones on the uptake of L-glutamate and L-aspartate by synaptosomes
Data(s) |
04/06/1974
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Resumo |
"Strong" excitants of central neurones such as β N-oxalyl L α,β-diaminopropionic acid (ODAP), N-methyl-D-aspartic acid (NMDA) and kainic acid (KA) were found to inhibit the high affinity uptake of glutamate and aspartate in synaptosomes isolated from young rat brain. The potency of these "strong" excitants as convulsants appear to parallel their ability to inhibit glutamate uptake by synaptosomes. The data suggest the possibility that the convulsive effect of these "strong" excitants could be mediated by glutamate/aspartate. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/23908/1/full.pdf Lakshmanan, J and Padmanaban, G (1974) Effect of some "strong" excitants of central neurones on the uptake of L-glutamate and L-aspartate by synaptosomes. In: Biochemical and Biophysical Research Communications, 58 (3). pp. 690-698. |
Publicador |
Elsevier Science |
Relação |
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4KY7V25-S&_user=512776&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000025298&_version=1&_urlVersion=0&_userid=512776&md5=d907e3cdf6d57f926ef93d74b74d0a85 http://eprints.iisc.ernet.in/23908/ |
Palavras-Chave | #Biochemistry |
Tipo |
Journal Article PeerReviewed |