Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India
Data(s) |
01/06/1987
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Resumo |
Consanguineous marriages are strongly favoured among the populations of South India. In a study conducted on 407 infants and children, a total of 35 genetic diseases was diagnosed in 63 persons: 44 with single gene defects, 12 with polygenic disorders, and seven with Down's syndrome. The coefficient of inbreeding of the total study group, F = 0.0414, was significantly higher than that previously calculated for the general population, F = 0.0271, and autosomal recessive disorders formed the largest single disease category diagnosed. The results suggest that long term inbreeding may not have resulted in appreciable elimination of recessive lethals and sub-lethals from the gene pool. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/21182/1/3.pdf Devi, AR and Rao, NA and Bittles, AH (1987) Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India. In: Journal of Medical Genetics, 24 (6). 362 -365. |
Publicador |
BMJ Publishing Group |
Relação |
http://jmg.bmj.com/cgi/content/abstract/24/6/362 http://eprints.iisc.ernet.in/21182/ |
Palavras-Chave | #Biochemistry |
Tipo |
Journal Article PeerReviewed |