Synthetic peptides as chemoattractants for bull spermatozoa structure activity correlations
Data(s) |
16/09/1980
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Resumo |
The ability of various synthetic peptide analogs of. Formyl-Met-Leu-Phe to induce chemotaxis in bull sperm is compared using an inverted capillary assay. The formyl group is essential for chemotactic activity and corresponding t-butyloxycarbonyl tripeptides are inactive. Sequence analogs, Formyl-Met-Phe-Leu, Formyl-Leu-Met-Phe and Formyl-Leu-Phe-Met are active. Replacement of Met and Leu by Pro does not diminish activity. Formyl-Met-Leu-Phe-NH2 is active suggesting that electrostatic interactions involving the carboxyl group may be unimportant in receptor interactions. The studies establish the importance of an amino terminal formyl group and a sequence of at least three hydrophobic residues, for inducing sperm chemotaxis. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/21096/1/fulltext.pdf Iqbal, M and Shivaji, S and Vijayasarathy, S and Balaram, P (1980) Synthetic peptides as chemoattractants for bull spermatozoa structure activity correlations. In: Biochemical and Biophysical Research Communications, 96 (1). pp. 235-242. |
Publicador |
Elsevier science |
Relação |
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4DYVHVW-1G5&_user=512776&_coverDate=09%2F16%2F1980&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000025298&_version=1&_urlVersion=0&_userid=512776&md5=9a63b7bb4cf44834756137 http://eprints.iisc.ernet.in/21096/ |
Palavras-Chave | #Molecular Biophysics Unit |
Tipo |
Journal Article PeerReviewed |