Adriamycin treatment increases 3-hydroxy-3-methylglutaryl CoA reductase and isoprene biosynthesis in the rat liver
Data(s) |
01/09/1980
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Resumo |
Treatment of rats with Adriamycin caused an increase in the incorporation into hepatic cholesterol of [1-14C] acetate, but not of [2-14C] mevalonate. The step affected was found to be 3-hydroxy-3-methylglutaryl CoA reductase whose activity in the liver microsomes increased in Adriamycin-treated animals, but was inhibited when the drug was added in the assay medium. Also, the concentration of ubiquinone in the liver and of cholesterol in the plasma increased. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/20875/1/full.pdf Menon, Satish A and Ramasarma, T (1980) Adriamycin treatment increases 3-hydroxy-3-methylglutaryl CoA reductase and isoprene biosynthesis in the rat liver. In: Biochemical and Biophysical Research Communications, 96 (2). pp. 939-945. |
Publicador |
Elsevier Science |
Relação |
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4DMXDNC-239&_user=512776&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000025298&_version=1&_urlVersion=0&_userid=512776&md5=7ccd9cc1898c985b0b5196b8f506c919 http://eprints.iisc.ernet.in/20875/ |
Palavras-Chave | #Biochemistry |
Tipo |
Journal Article PeerReviewed |