Conformational transitions in a Pro-Pro peptide on dissolution of single crystals


Autoria(s): Balaram, Hemalatha; Prasad, B V Venkataram; Balaram, Padmanabhan
Data(s)

1982

Resumo

The peptide t-butyloxycarbonyl-α-aminoisobutyryl-L-prolyl-L-prolyl-N-methylamide has been shown to adopt an extended structure in the solid state. The Pro-Pro segment occurs in the poly-proline II conformation. On dissolution of single crystals at not, vert, similar 233°K, a single species corresponding to the all Image peptide backbone is observed by 270 MHz 1H NMR. On warming, Image to Image isomerization about the Pro-Pro bond is facilitated. Both Image (ψ not, vert, similar−50°) and Image (ψ not, vert, similar 130°) rotamers about the Pro3 Cα---CO bond are detectable in the Pro-Pro Image conformer, at low temperature. These observations demonstrate unambiguously the large differences in the solid state and solution conformations of a Pro-Pro sequence.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/20123/1/fulltext.pdf

Balaram, Hemalatha and Prasad, B V Venkataram and Balaram, Padmanabhan (1982) Conformational transitions in a Pro-Pro peptide on dissolution of single crystals. In: Biochemical and Biophysical Research Communications, 109 (3). pp. 825-831.

Publicador

Elsevier Science

Relação

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBK-4DNJ0MR-17J-5&_cdi=6713&_user=512776&_orig=search&_coverDate=12%2F15%2F1982&_sk=998909996&view=c&wchp=dGLbVzz-zSkWA&md5=955649b4f5c366d70900070d706bc8a2&ie=/sdarticle.pdf

http://eprints.iisc.ernet.in/20123/

Palavras-Chave #Molecular Biophysics Unit
Tipo

Journal Article

PeerReviewed