DC-SIGN and alpha 2,6-sialylated IgG Fc interaction is dispensable for the anti-inflammatory activity of IVIg on human dendritic cells
| Data(s) |
01/03/2009
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|---|---|
| Resumo |
Intravenous immunoglobulin (IVIg) is widely used to treat autoimmune diseases. Several mutually nonexclusive mechanisms are proposed to explain the beneficial effects of IVIg in patients (1, 2). Lately, Ravetch and colleagues (3) demonstrate that anti-inflammatory activity of IVIg is mediated mainly by antibodies that contain terminal _2,6-sialic acid linkages at the Asn297-linked glycan of Fc region. |
| Formato |
application/pdf |
| Identificador |
http://eprints.iisc.ernet.in/19632/1/1.pdf Bayry, Jagadeesh and Bansal, Kushagra and Kazatchkine, Michel D and Kaveri, Srini V (2009) DC-SIGN and alpha 2,6-sialylated IgG Fc interaction is dispensable for the anti-inflammatory activity of IVIg on human dendritic cells. In: Proceedings Of The National Academy Of Sciences Of The United States Of America, 106 (9). E24. |
| Publicador |
National Academy of Sciences |
| Relação |
http://www.pnas.org/content/106/9/E24.full.pdf+html http://eprints.iisc.ernet.in/19632/ |
| Palavras-Chave | #Microbiology & Cell Biology |
| Tipo |
Journal Article PeerReviewed |
