Altered immunoglobulin E diversity and regulation of allergic inflammation in asthma
Data(s) |
01/04/2009
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Resumo |
The clinical efficacy of anti-immunoglobulin E (IgE) therapy indicates a central role for IgE in perpetuation of allergic inflammatory diseases. Omalizumab is now uti- lized in treatment of a wide variety of allergic conditions including severe asthma, allergic rhinitis, atopic dermati- tis, food allergy and urticaria either alone or adjunct with other therapies such as steroid administration or allergen- specific immunotherapy [1, 2]. Current research activity is focused on the cellular and molecular mechanisms by which IgE influences the immunopathogenesis of allergic disease [3]. Increased knowledge of how IgE exerts its effects will underpin effective clinical use of anti-IgE treatment. In this issue Kerzel et al. [4] investigate the effects of altered antibo dy repertoire on the outcomes of an experimental model of allergic asthma. |
Identificador | |
Publicador |
Wiley-Blackwell Publishing Ltd. |
Relação |
DOI:10.1111/j.1365-2222.2009.03231.x Davies, J. M. (2009) Altered immunoglobulin E diversity and regulation of allergic inflammation in asthma. Clinical and Experimental Allergy, 39(4), pp. 455-457. |
Direitos |
Copyright 2009 Wiley-Blackwell Publishing Ltd. |
Palavras-Chave | #allergen #chemokine #cytokine #immunoglobulin E #immunoglobulin E antibody #immunoglobulin heavy chain #immunoglobulin light chain #omalizumab #steroid #allergic asthma #allergic reaction #biodiversity #complementarity determining region #editorial #genetic variability #human #immunoglobulin blood level #immunopathogenesis #immunoregulation #immunotherapy #inflammation #molecular dynamics #nonhuman #priority journal #protein function #sensitization #Animals #Asthma #B-Lymphocytes #Cytokines #Humans #Mice #Somatic Hypermutation #Immunoglobulin |
Tipo |
Journal Article |