The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis
Data(s) |
1998
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Resumo |
The role of germline polymorphisms of the T-cell receptor A/D and B loci in susceptibility to ankylosing spondylitis was investigated by linkage studies using microsatellite markers in 215 affected sibling pairs. The presence of a significant susceptibility gene (lambda ≤ 1.6) at the TCRA/D locus was excluded (LOD score < -2.0). At the TCRB locus, there was weak evidence of the presence of a susceptibility gene (P = 0.01, LOD score 1.1). Further family studies will be required to determine whether this is a true or false-positive finding. It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis. |
Identificador | |
Publicador |
Oxford University Press |
Relação |
DOI:10.1093/rheumatology/37.4.454 Brown, M.A., Rudwaleit, M., Pile, K. D., Kennedy, L. G., Shatford, J., Amos, C. I., Siminovitch, K., Rubin, L., Calin, A., & Wordsworth, B. P. (1998) The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis. British Journal of Rheumatology, 37(4), pp. 454-458. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #Ankylosing spondylitis #Genetics #Linkage #Microsatellite #Polymorphism #Spondyloarthritis #T-cell receptor #microsatellite dna #t lymphocyte receptor #article #controlled study #dna polymorphism #family study #genetic linkage #genetic susceptibility #human #major clinical study #normal human #priority journal #sibling #Family Health #Female #Genetic Heterogeneity #Germ-Line Mutation #Humans #Linkage (Genetics) #Male #Microsatellite Repeats #Nuclear Family #Polymorphism #Genetic #Receptors #Antigen #T-Cell #Spondylitis #Ankylosing |
Tipo |
Journal Article |