The role of endogenous scabies mite complement inhibitors in the development of Streptococcus pyogenes skin infections
Data(s) |
2015
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Resumo |
This project expands upon the discovery that scabies mites produce protein molecules that interfere with the human complement cascade, disrupting a critical component of the early stages of the host immune response. This is believed to provide an optimal environment for the development of commonly associated secondary bacterial infections. The thesis investigated the effect of two distinct scabies mite proteins, namely SMS B4 and SMIPP-S I1, on the in vitro proliferation of Group A Streptococcus in whole human blood. Additionally, in vitro immunoassays were performed to determine if complement mediated opsonisation and phagocytosis were also disrupted. |
Formato |
application/pdf |
Identificador | |
Publicador |
Queensland University of Technology |
Relação |
http://eprints.qut.edu.au/86523/1/Lindsay_Christian_Thesis.pdf Christian, Lindsay Darryl (2015) The role of endogenous scabies mite complement inhibitors in the development of Streptococcus pyogenes skin infections. Masters by Research thesis, Queensland University of Technology. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #Scabies #Streptococcus pyogenes #secondary bacterial infection #complement #opsonisation #phagocytosis |
Tipo |
Thesis |