Targeting and transport : how microtubules control focal adhesion dynamics
Data(s) |
2012
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Resumo |
Directional cell migration requires force generation that relies on the coordinated remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin-based focal adhesions (FAs). Normal FA turnover requires dynamic microtubules, and three members of the diverse group of microtubule plus-end-tracking proteins are principally involved in mediating microtubule interactions with FAs. Microtubules also alter the assembly state of FAs by modulating Rho GTPase signaling, and recent evidence suggests that microtubule-mediated clathrin-dependent and -independent endocytosis regulates FA dynamics. In addition, FA-associated microtubules may provide a polarized microtubule track for localized secretion of matrix metalloproteases (MMPs). Thus, different aspects of the molecular mechanisms by which microtubules control FA turnover in migrating cells are beginning to emerge. |
Identificador | |
Publicador |
Rockefeller University Press |
Relação |
DOI:10.1083/jcb.201206050 Stehbens, Samantha & Wittmann, Torsten (2012) Targeting and transport : how microtubules control focal adhesion dynamics. The Journal of Cell Biology, 198(4), pp. 481-489. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #100400 MEDICAL BIOTECHNOLOGY #animals #endocytosis #extracellular matrix #focal adhesions #microtubules #signal transduction #humans |
Tipo |
Journal Article |