Growth factors in induction of epithelial-mesenchymal transition and metastasis
Data(s) |
2011
|
---|---|
Resumo |
Epithelial to mesenchymal transition (EMT) has gained widespread acceptance over recent years as a mechanism by which normally sessile epithelial tumour cells can move away from the primary tumour and metastasize. This review article examines the role of a number of growth factors in inducing EMT, and the reverse process mesenchymal to epithelial transition. Unique and common intracellular signalling pathways are highlighted. A comprehensive understanding of the regulation of EMT will be critical in manipulating this process to develop novel anti-metastasis therapies. |
Identificador | |
Publicador |
S. Karger AG |
Relação |
DOI:10.1159/000320360 Said, Nur Akmarina B.M. & Williams, Elizabeth D. (2011) Growth factors in induction of epithelial-mesenchymal transition and metastasis. Cells Tissues Organs, 193(1-2), pp. 85-97. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #111201 Cancer Cell Biology #Epithelial to mesenchymal transition #metastasis #growth factors |
Tipo |
Journal Article |