Re-evaluation of the effect of smoking on the methylation of N-terminal valine in haemoglobin
Data(s) |
09/07/2001
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Resumo |
In view of the established extrapulmonary cancer sites targeted by smoking a multiplicity of compounds, and mechanisms might be involved. It has been debated that smoking caused increased incidence of N-methylvaline at the N-terminus of haemoglobin. Because this could indicate a relevance of methylating nitrosamines in tobacco smoke, data are presented from an industrial cohort of 35 smokers and 21 non-smokers repeatedly monitored between 1994 and 1999. In general, N-methylvaline adduct levels in haemoglobin of smokers were approximately 50% higher than those of non-smokers. The smoking-induced methylation of haemoglobin is likely to be caused by dimethylnitrosamine (N-nitroso-dimethylamine), a major nitrosamine in side-stream tobacco smoke. The biomonitoring data emphasise the potential value of N-methylvaline as a smoking-related biomarker and call for intensified research on tobacco smoke compounds that lead to macromolecular methylation process. |
Identificador | |
Publicador |
Springer |
Relação |
http://link.springer.com/article/10.1007/s002040100235 DOI:10.1007/s002040100235 Thier, R., Lewalter, J., Selinski, S., & Bolt, H. M. (2001) Re-evaluation of the effect of smoking on the methylation of N-terminal valine in haemoglobin. Archives of Toxicology, 75(5), pp. 270-273. |
Direitos |
Copyright 2001 Springer-Verlag |
Fonte |
School of Clinical Sciences; Faculty of Health |
Palavras-Chave | #Dimethylnitrosamine #Haemoglobin adducts #N-Alkylvaline #N-Cyanoethylvaline #N-Hydroxyethylvaline #N-Methylvaline #Nitrosamines #Smoking #Tobacco smoke #nitrosamine #valine #amino terminal sequence #article #biological monitoring #cancer risk #chemical carcinogenesis #clinical article #controlled study #hemoglobin determination #human #methylation #priority journal #Cohort Studies #Hemoglobins #Humans #Tobacco Smoke Pollution #Nicotiana tabacum |
Tipo |
Journal Article |