Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972


Autoria(s): Thompson, Mary F.; Totsika, Makrina; Schembri, Mark A.; Mills, Paul C.; Seton, Erica J.; Trott, Darren J.
Data(s)

10/01/2011

Resumo

Establishment of asymptomatic bacteriuria (ABU) with Escherichia coli 83972 is a viable prophylactic alternative to antibiotic therapy for the prevention of recurrent bacterial urinary tract infection in humans. Approximately 2 x 108 viable E. coli 83972 cells were introduced into the bladder of six healthy female dogs via a sterile urinary catheter. The presence of pyuria, depression, stranguria, pollakiuria and haematuria was documented for 6 weeks and urinalysis and aerobic bacterial cultures were performed every 24–72 h. Pyuria was present in all dogs on day 1 post-inoculation and 4/6 dogs (67%) had a positive urine culture on this day. Duration of colonization ranged from 0 to 10 days (median 4 days). Four dogs were re-inoculated on day 20. Duration of colonization following the second inoculation ranged from 1 to 3 days. No dog suffered pyrexia or appeared systemically unwell but all dogs initially exhibited mild pollakiuria and a small number displayed gross haematuria and/or stranguria. By day 3 of each trial all clinical signs had resolved. Persistent bacteriuria was not achieved in any dog but two dogs were colonized for 10 days following a single inoculation. Further research is required to determine whether establishment of ABU in dogs with recurrent urinary tract infection is a viable alternative to repeated doses of antimicrobial agents.

Identificador

http://eprints.qut.edu.au/77402/

Publicador

Elsevier BV

Relação

DOI:10.1016/j.vetmic.2010.06.007

Thompson, Mary F., Totsika, Makrina, Schembri, Mark A., Mills, Paul C., Seton, Erica J., & Trott, Darren J. (2011) Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972. Veterinary Microbiology, 147(1-2), pp. 205-208.

Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation

Palavras-Chave #Urinary tract infection #Bacteriuria #Canine #Bacterial interference #Colonization
Tipo

Journal Article