Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection
| Data(s) |
2013
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|---|---|
| Resumo |
Urinary tract infections (UTI) are among the most common infectious diseases of humans and are the most common nosocomial infections in the developed world. It is estimated that 40–50% of women and 5% of men will develop a UTI in their lifetime, and UTI accounts for more than 1 million hospitalizations and $1.6 billion in medical expenses each year in the USA. Uropathogenic Escherichia coli (UPEC) is the primary cause of UTI. This review presents an overview of recent discoveries related to the primary virulence factors of UPEC and major innate immune responses to infection of the lower urinary tract. New and emerging themes in UPEC research are discussed in the context of the interface between host and pathogen. |
| Identificador | |
| Publicador |
Elsevier |
| Relação |
DOI:10.1016/j.mib.2013.01.005 Ulett, Glen C., Totsika, Makrina, Schaale, Kolja, Carey, Alison J., Sweet, Matthew J., & Schembri, Mark A. (2013) Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection. Current Opinion in Microbiology, 16(1), pp. 100-107. |
| Direitos |
Copyright 2013 Elsevier This is the author’s version of a work that was accepted for publication in Current Opinion in Microbiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Current Opinion in Microbiology, [VOL 16, ISSUE 1, (2013)] DOI: 10.1016/j.mib.2013.01.005 |
| Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
| Palavras-Chave | #060501 Bacteriology #110707 Innate Immunity #urinary tract infection #innate immunity #uropathogenic E. coli |
| Tipo |
Review |
