Speckle-type POZ protein mutations interrupt tumor suppressor function of speckle-type POZ protein in prostate cancer by affecting androgen receptor degradation
Data(s) |
17/06/2014
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Resumo |
Large scale exome sequencing studies have revealed regions of the genome, which contribute to the castrate resistant prostate cancer (CRPC) phenotype. [1],[2],[3] Such studies have identified mutations in genes, which may have diagnostic/prognostic potential, or which may be targeted therapeutically. Two of these genes include the androgen receptor (AR) and speckle-type POZ protein (SPOP) genes. However, the findings from these exome sequencing studies can only be translated therapeutically once the functional consequences of these mutations have been determined. Here, we highlight the recent study by An et al. [4] which investigated the functional effects of mutations in the SPOP gene that were identified in the aforementioned exome sequencing studies, particularly in the context of SPOP-mediated degradation of the AR. |
Identificador | |
Publicador |
Wolters Kluwer Health - Medknow |
Relação |
DOI:10.4103/1008-682X.133323 Lai, John & Batra, Jyotsna (2014) Speckle-type POZ protein mutations interrupt tumor suppressor function of speckle-type POZ protein in prostate cancer by affecting androgen receptor degradation. Asian Journal of Andrology, 16(5), pp. 659-660. |
Direitos |
Copyright 2014 Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #110106 Medical Biochemistry - Proteins and Peptides (incl. Medical Proteomics) #111201 Cancer Cell Biology #111203 Cancer Genetics #speckle-type POZ #protein mutations #tomore suppression #prostate cancer #androgen receptor degradation |
Tipo |
Journal Article |