Induction of tumorigenicity by galectin-3 in a nontumorigenic human breast-carcinoma cell-line
Data(s) |
1995
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Resumo |
The human galectin-3 is a galactoside-binding protein of 31 kDa which functions as a receptor for glycoproteins containing poly N-acetyllactosamine side chains and as a substrate for matrix metalloproteinases-2 and -9. We studied its expression by flow cytofluorimetry, Western, Northern and Southern analyses, in five cultured human breast carcinoma cell lines previously characterized as non-tumorigenic, poorly metastatic or metastatic in nude mice. The expression of galectin-3 correlated with the reported tumorigenicity of the cells. The introduction of recombinant galectin-3 into the null expressing non-tumorigenic BT-549 cells resulted in the acquisition of anchorage-independent growth properties in alland tumorigenicity in 3/4 sense transfected cell crones. The data indicate a relationship between galectin-3 expression and malignancy of human breast carcinoma cell lines. |
Identificador | |
Publicador |
Spandidos Publications |
Relação |
http://www.spandidos-publications.com/ijo/7/5/1079 DOI:10.3892/ijo.7.5.1079 Nangia-Makker, P., Thompson, Erik W., Hogan, C., Ochieng, J., & Raz, A. (1995) Induction of tumorigenicity by galectin-3 in a nontumorigenic human breast-carcinoma cell-line. International Journal of Oncology, 7(5), pp. 1079-1087. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #Breast cancer #Galectin-3 #Lectin #Transfection #Tumorigenicity |
Tipo |
Journal Article |