Enantioselective epoxidation of linolenic acid catalysed by cytochrome P450BM3 from Bacillus megaterium
| Data(s) |
2005
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|---|---|
| Resumo |
Cytochrome P450BM3, from Bacillus megaterium, catalyses the epoxidation of linolenic acid 1 yielding 15,16-epoxyoctadeca-9,12-dienoic acid 2 with complete regio- and moderate enantio-selectivity (60% ee). The absolute configuration of the product is tentatively assigned as 15(R),16(S)-. The Michaelis–Menten parameters kcat and Km for the reaction were determined to be 3126 ± 226 min−1 and 24 ± 6 μM respectively. |
| Formato |
application/pdf |
| Identificador | |
| Publicador |
Royal Society of Chemistry |
| Relação |
http://eprints.qut.edu.au/70983/1/70983.pdf DOI:10.1039/B506155E Çelik, Ayhan, Sperandio, Davide, Speight, Robert E., & Turner, Nicholas J. (2005) Enantioselective epoxidation of linolenic acid catalysed by cytochrome P450BM3 from Bacillus megaterium. Organic & Biomolecular Chemistry, 3(15), pp. 2688-2690. |
| Direitos |
Copyright 2005 Royal Society of Chemistry |
| Fonte |
School of Chemistry, Physics & Mechanical Engineering; Science & Engineering Faculty |
| Tipo |
Journal Article |
