The mouse model of Chlamydia genital tract infection: a review of infection, disease, immunity and vaccine development
Data(s) |
2014
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Resumo |
Chlamydia trachomatis is the most common sexually transmitted bacterial infection worldwide. The impact of this pathogen on human reproduction has intensified research efforts to better understand chlamydial infection and pathogenesis. Whilst there are animal models available that mimic the many aspects of human chlamydial infection, the mouse is regarded as the most practical and widely used of the models. Studies in mice have greatly contributed to our understanding of the host-pathogen interaction and provided an excellent medium for evaluating vaccines. Here we explore the advantages and disadvantages of all animal models of chlamydial genital tract infection, with a focus on the murine model and what we have learnt from it so far. |
Identificador | |
Publicador |
Bentham Science Publishers |
Relação |
http://benthamscience.com/journal/index.php?journalID=cmm O'Meara, Connor, Andrew, Dean, & Beagley, Kenneth (2014) The mouse model of Chlamydia genital tract infection: a review of infection, disease, immunity and vaccine development. Current Molecular Medicine, 14(2). http://purl.org/au-research/grants/NHMRC/553026 |
Direitos |
Copyright 2014 Bentham Science Publishers |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #110799 Immunology not elsewhere classified #110802 Medical Infection Agents (incl. Prions) #119999 Medical and Health Sciences not elsewhere classified #Chlamydia #Animal models #Vaccine |
Tipo |
Journal Article |