Strategies and challenges for systematically mapping biologically significant molecular pathways regulating carcinoma epithelial-mesenchymal transition
Data(s) |
01/07/2013
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Resumo |
Enormous progress has been made towards understanding the role of specific factors in the process of epithelial-mesenchymal transition (EMT); however, the complex underlying pathways and the transient nature of the transition continues to present significant challenges. Targeting tumour cell plasticity underpinning EMT is an attractive strategy to combat metastasis. Global gene expression profiling and high-content analyses are among the strategies employed to identify novel EMT regulators. In this review, we highlight several approaches to systematically interrogate key pathways involved in EMT, with particular emphasis on the features of multiparametric, high-content imaging screening strategies that lend themselves to the systematic discovery of highly significant modulators of tumour cell plasticity. |
Identificador | |
Publicador |
S. Karger AG |
Relação |
http://www.karger.com/Article/FullText/351717 DOI:10.1159/000351717 Said, Nur Akmarina B.M., Simpson, Kaylene J., & Williams, Elizabeth D. (2013) Strategies and challenges for systematically mapping biologically significant molecular pathways regulating carcinoma epithelial-mesenchymal transition. Cells Tissues Organs, 197(6), pp. 424-434. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #111200 ONCOLOGY AND CARCINOGENESIS #111201 Cancer Cell Biology #epthelial-to-mesenchymal transition #plasticity #high-content screen |
Tipo |
Journal Article |