Differences between first episode schizophrenia and schizoaffective disorder


Autoria(s): Cotton, S.M.; Lambert, M.; Schimmelmann, B.G.; MacKinnon, A.; Gleeson, J.F.M.; Berk, M.; Hides, L.; Chanen, A.M.; Scott, J.; Schöttle, D.; McGorry, P.D.; Conus, P.
Data(s)

01/06/2013

Resumo

Background: The diagnostic and clinical overlap between schizophrenia and schizoaffective disorder is an important nosological issue in psychiatry that is yet to be resolved. The aim of this study was to compare the clinical and functional characteristics of an epidemiological treated cohort of first episode patients with an 18-month discharge diagnosis of schizophrenia (FES) or schizoaffective disorder (FESA). Methods: This study was part of the larger First Episode Psychosis Outcome Study (FEPOS) which involved a medical file audit study of all 786 patients treated at the Early Psychosis Prevention and Intervention Centre between 1998 and 2000. Of this cohort, 283 patients had a 18-month discharge diagnosis of FES and 64 had a diagnosis of FESA. DSM-IV diagnoses, clinical and functional ratings were derived and validated by two consultant psychiatrists. Results: Compared to FES patients, those with FESA were significantly more likely to have a later age of onset (p=.004), longer prodrome (p=.020), and a longer duration of untreated psychosis (p<.001). At service entry, FESA patients presented with a higher illness severity (p=.020), largely due to the presence of more severe manic symptoms (p<.001). FESA patients also had a greater number of subsequent inpatient admissions (p=.017), had more severe depressive symptoms (p=.011), and higher levels of functioning at discharge. Discussion: The findings support the notion that these might be considered two discernable disorders; however, further research is required to ascertain the ways and extent to which these disorders are discriminable at presentation and over time.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/67108/

Publicador

Elsevier

Relação

http://eprints.qut.edu.au/67108/1/Cotton_autherversion_SchizRes_2013.pdf

http://www.sciencedirect.com/science/article/pii/S0920996413001400

DOI:10.1016/j.schres.2013.02.036

Cotton, S.M., Lambert, M., Schimmelmann, B.G., MacKinnon, A., Gleeson, J.F.M., Berk, M., Hides, L., Chanen, A.M., Scott, J., Schöttle, D., McGorry, P.D., & Conus, P. (2013) Differences between first episode schizophrenia and schizoaffective disorder. Schizophrenia Research, 147(1), pp. 169-174.

Direitos

Copyright 2013 Elsevier B.V.

NOTICE: this is the author’s version of a work that was accepted for publication in Schizophrenia Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Schizophrenia Research, [Volume 147, Issue 1, (June 2013)] DOI: 10.1016/j.schres.2013.02.036

Fonte

Faculty of Health; Institute of Health and Biomedical Innovation; School of Psychology & Counselling

Palavras-Chave #110000 MEDICAL AND HEALTH SCIENCES #170000 PSYCHOLOGY AND COGNITIVE SCIENCES #Schizophrenia #Schizoaffective disorder #first episode psychosis #diagnosis #depression #mania #psychosis
Tipo

Journal Article