Potential role of bcl-2 as a suppressor of tumour angiogenesis in non- small-cell lung cancer
Data(s) |
1997
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Resumo |
It has been reported that genes regulating apoptosis may play a role in tumoral angiogenesis. This study examined the relationship between tumour vascularization, a measure of tumour angiogenesis, and bcl-2 and p53 expression in operable non-small-cell lung cancer (NSCLC). The relationship between bcl-2, p53 and tumour vascularization and epidermal-growth-factor- receptor(EGFR) and c-erbB-2 expression was also studied. Tissue sections from resected tumour specimens of 107 NSCLC patients were evaluated immunohistochemically for vascular grade and bcl-2, p53, EGFR and c-erbB-2 expression. bcl-2 expression was found in 20/107 (19%) cases and was associated with squamous-cell histology (p = 0.03). A strong inverse relationship was found between bcl-2 expression and vascular grade (p = 0.005). All c-erbB-2-positive cases were negative for bcl-2 expression (p = 0.01). Overall no association was found between c-erbB-2 expression and vascular grade. However, in bcl-2-negative cases positive c-erbB-2 expression correlated with low angiogenesis (p = 0.05). No relationship was found between p53 and EGFR expression and bcl-2, c-erbB-2 or vascular grade. The improved prognosis reported in bcl-2-positive NSCLC may be related to low tumour vascularization. The results suggest that the anti-apoptotic gene bcl- 2 plays a role in regulating tumour angiogenesis. Since normal lung epithelium expresses bcl-2, a sequence of tumour progression involving loss of bcl-2, then activation of c-erbB-2 or increase in tumour vascularization is proposed. |
Identificador | |
Publicador |
John Wiley & Sons, Inc. |
Relação |
DOI:10.1002/(SICI)1097-0215(19971219)74:6<565::AID-IJC1>3.0.CO;2-S Koukourakis, M. I., Giatromanolaki, A., O'Byrne, Kenneth J., Whitehouse, R. M., Talbot, D. C., Gatter, K. C., & Harris, A. L. (1997) Potential role of bcl-2 as a suppressor of tumour angiogenesis in non- small-cell lung cancer. International Journal of Cancer, 74(6), pp. 565-570. |
Direitos |
Copyright 1997 John Wiley & Sons, Inc. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #epidermal growth factor receptor #protein bcl 2 #protein p53 #tyrosine kinase receptor #adult #aged #angiogenesis #apoptosis #article #cancer grading #cancer growth #female #gene expression #human #immunohistochemistry #lung cancer #lung non small cell cancer #major clinical study #male #priority journal #Analysis of Variance #Carcinoma #Non-Small-Cell Lung #Genes #bcl-2 #Genes #p53 #Genes #Tumor Suppressor #Humans #Lung Neoplasms #Middle Aged #Neovascularization #Pathologic #Proto-Oncogene Proteins c-bcl-2 #Receptor Protein-Tyrosine Kinases #Receptor #Epidermal Growth Factor #Retrospective Studies #Survival Analysis #Tumor Suppressor Protein p53 |
Tipo |
Journal Article |