Endophenotype profiles of MTHFR and ACE gene polymorphisms in migraine susceptibility


Autoria(s): Liu, A.; Colson, Natalie J.; Quinlan, S.; Peterson, M.; Lea, R. A.; Griffiths, Lyn R.
Resumo

Background Migraine is a debilitating neurological disorder affecting approximately 12% of the Caucasian population. There are two main sub-types of migraine, migraine without aura (MO) and migraine with aura (MA). Migraine exhibits varied phenotypic expression with sufferers experiencing a range of neurological and other symptoms. It is likely that multiple susceptibility genes play a role in this varied phenotypic expression, thus investigation of genotype-phenotype relationships may provide valuable insights into the role of susceptibility genes in this disorder. Methods This study investigated the links between migraine susceptibility genes, methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE), and clinical manifestation through statistical analyses. Results The result showed that for the MTHFR genotypes, there was a statistically significant correlation with the TT homozygous genotype and visual disturbances, unilateral head pain and physical activity discomforts. It was also found that bilateral head pain was associated with the male gender. Conclusion From these study results, it is plausible to state that MTHFR genotypes affect the phenotypic expression of migraine disease manifestation.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/63663/

Relação

http://eprints.qut.edu.au/63663/1/63663.pdf

Liu, A., Colson, Natalie J., Quinlan, S., Peterson, M., Lea, R. A., & Griffiths, Lyn R. Endophenotype profiles of MTHFR and ACE gene polymorphisms in migraine susceptibility. [Working Paper] (Unpublished)

Direitos

Copyright the authors

Fonte

Institute of Health and Biomedical Innovation

Tipo

Working Paper