Association of a RFLP for the insulin receptor gene, but not insulin, with essential hypertension
Data(s) |
1991
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Resumo |
Insulin has cardiovascular actions and patients with essential hypertension display insulin resistance. A cross-sectional study of the R1 RFLP of the insulin receptor gene (INSR) was carried out in 67 hypertensive (HT) and 75 normotensive (NT) subjects whose parents had a similar blood pressure status at age ≥50. The frequency of the minor (+) allele was 0.31 in HTs and 0.44 in NTs, and the difference between observed alleles in all subjects in each group was significant (χ2 = 4.8, P<0.05). Allele frequencies of a BglI RFLP of the insulin gene, however, did not differ between the HT and NT groups. The data thus provide evidence in favour of an association of HT with a polymorphism at the INSR locus (19p 13.3-13.2), so implicating this locus, and possibly a genetic variant of the insulin receptor itself, in HT. |
Identificador | |
Publicador |
Elsevier Inc. |
Relação |
http://www.scopus.com/inward/record.url?eid=2-s2.0-0026332336&partnerID=40&md5=0c3f96f0ba6aeaa2fb5942a0cebd5c81 Ying, L.-H., Zee, R. Y., Griffiths, Lyn R., & Morris, B. J. (1991) Association of a RFLP for the insulin receptor gene, but not insulin, with essential hypertension. Biochemical and Biophysical Research Communications, 181(1), pp. 486-492. |
Direitos |
Copyright 1991 Elsevier Inc. |
Fonte |
Institute of Health and Biomedical Innovation |
Palavras-Chave | #insulin receptor #article #controlled study #essential hypertension #human #insulin resistance #major clinical study #priority journal #restriction fragment length polymorphism #Adult #Aged #Alleles #Blood Pressure #Chromosome Mapping #Chromosomes #Human #Pair 19 #Deoxyribonucleases #Type II Site-Specific #DNA #DNA Probes #Gene Frequency #Genotype #Human #Hypertension #Insulin #Leukocytes #Polymorphism #Restriction Fragment Length #Receptor #Insulin #Reference Values #Support #Non-U.S. Gov't |
Tipo |
Journal Article |