Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs
Data(s) |
01/05/2013
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Resumo |
Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness and swelling properties. GelMA solutions have a low viscosity at 37 °C, which is incompatible with most biofabrication approaches. However, incorporation of hyaluronic acid (HA) and/or co-deposition with thermoplastics allows gelMA to be used in biofabrication processes. These attributes may allow engineered constructs to match the natural functional variations in cartilage mechanical and geometrical properties. |
Formato |
application/pdf |
Identificador | |
Publicador |
Wiley - V C H Verlag GmbH & Co. KGaA |
Relação |
http://eprints.qut.edu.au/62072/2/Schuurman_GelMA_2013_QUT_eprints.pdf DOI:10.1002/mabi.201200471 Schuurman, Wouter, Levett, Peter A., Pot, Michiel W., van Weeren, Paul René, Dhert, Wouter J. A., Hutmacher, Dietmar W., Melchels, Ferry P. W., Klein, Travis J., & Malda, Jos (2013) Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs. Macromolecular Bioscience, 13(5), pp. 551-561. |
Direitos |
Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
Fonte |
School of Chemistry, Physics & Mechanical Engineering; Institute of Health and Biomedical Innovation; Science & Engineering Faculty |
Palavras-Chave | #090301 Biomaterials #100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering) #Hydrogels #Gelatin #Cartilage #Photopolymerisation |
Tipo |
Journal Article |