Do RNA viruses require genome cyclisation for replication?
Data(s) |
29/04/2013
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Resumo |
Complementary sequences at the 5′ and 3′ ends of the dengue virus RNA genome are essential for viral replication, and are believed to cyclise the genome through long-range base pairing in cis. Although consistent with evidence in the literature, this view neglects possible biologically active multimeric forms that are equally consistent with the data. Here, we propose alternative multimeric structures, and suggest that multigenome noncovalent concatemers are more likely to exist under cellular conditions than single cyclised monomers. Concatemers provide a plausible mechanism for the dengue virus to overcome the single-stranded (+)-sense RNA virus dilemma, and can potentially assist genome transport from the virus-induced vesicles into the cytosol. |
Formato |
application/pdf |
Identificador | |
Publicador |
Elsevier |
Relação |
http://eprints.qut.edu.au/60782/1/1-s2.0-S0968000413000741-main.pdf DOI:10.1016/j.tibs.2013.04.005 Lott, William B. & Doran, Michael R. (2013) Do RNA viruses require genome cyclisation for replication? Trends in Biochemical Sciences, 38(7), pp. 350-355. |
Direitos |
Copyright 2013 Elsevier |
Fonte |
School of Biomedical Sciences; School of Chemistry, Physics & Mechanical Engineering; Faculty of Health; Institute of Health and Biomedical Innovation; Science & Engineering Faculty |
Palavras-Chave | #060407 Genome Structure and Regulation #060500 MICROBIOLOGY #060506 Virology #Dengue #cyclisation #replication |
Tipo |
Journal Article |