Adaptive radiotherapy for virally mediated head and neck cancer
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08/03/2013
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Resumo |
Purpose: Virally mediated head and neck cancers (VMHNC) often present with nodal involvement, and are generally considered radioresponsive, resulting in the need for plan adaptation during radiotherapy in a subset of patients. We sought to identify a high-risk group based on pre-treatment nodal size to be evaluated in a future prospective adaptive radiotherapy trial. Methodology: Between 2005-2010, 121 patients with virally-mediated, node positive nasopharyngeal or oropharyngeal cancers, receiving definitive radiotherapy were reviewed. Patients were analysed based on maximum size of the dominant node at diagnosis with a view to grouping them in varying risk categories for the need of re-planning. The frequency and timing of the re-planning scans were also evaluated. Results: Sixteen nasopharyngeal and 105 oropharyngeal tumours were reviewed. Twenty-five (21%) patients underwent a re-planning CT at a median of 22 (range, 0-29) fractions with 1 patient requiring re-planning prior to the commencement of treatment. Based on the analysis, patients were subsequently placed into 3 groups defined by pre-treatment nodal size; ≤ 35mm (Group 1), 36-45mm (Group 2), ≥ 46mm (Group 3). Applying these groups to the patient cohort, re-planning CT’s were performed in Group 1- 8/68 (11.8%), Group 2- 4/28 (14.3%), Group 3- 13/25 (52%). Conclusion: In this series, patients with VMHNC and nodal size > 46mm appear to be a high-risk group for the need of plan adaptation during a course of definitive radiotherapy. This finding will now be tested in a prospective adaptive radiotherapy study. |
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application/pdf |
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Relação |
http://eprints.qut.edu.au/57277/1/E_Brown_ASMMIRT_2013_presentation.pdf Brown, Elizabeth, Porceddu, Sandro, Owen, Rebecca, & Harden, Fiona (2013) Adaptive radiotherapy for virally mediated head and neck cancer. In AIR Annual Scientific Meeting for Medical Imaging and Radiation Therapy, March 2013, Hobart, TAS. (Unpublished) |
Direitos |
Copyright 2013 The Authors |
Fonte |
School of Clinical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #110399 Clinical Sciences not elsewhere classified #Radiation Therapy #Head and neck cancer #Virus |
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Conference Item |