Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping

Autoria(s): Eeles, R.A.; Al Olama , A.A.; Benlloch, S.; Saunders, E.J.; Leongamornlert, D.A.; Tymrakiewicz , M.; Ghoussaini , M.; Luccarini, C.; Dennis, J.; Jugurnauth-Little, S.; Dadaev, T.; Neal, D.E.; Hamdy, F.C.; Donovan, J.L.; Muir, K.; Giles, G.G.; Severi, G.; Wiklund, F.; Gronberg, H.; Haiman , C.A.; Schumacher, F.; Henderson , B.E.; Marchand, L.L; Lindstrom, S.; Kraft, P.; Hunter, D.J.; Gapstur, S.; Chanock, S.; Berndt, S.I.; Albanes, D.; Andriole, G.; Schleutker, J.; Weischer, M.; Canzian, F.; Riboli, A.; Key, T.J.; Travis, R.C.; Campa, D.; Ingles, S.A.; John, E.M.; Hayes, R.B.; Pharoah, P.; Pashayan, N.; Khaw, K-T.; Stanford, J.L.; Ostrander, E.A.; Signorello, L.B.; Thibodeau, S.N.; Schaid, D.; Maier, C.; Vogel, W.; Kibel, S.A.; Cybulski, C.; Lubinski, J.; Cannon-Albright, L.; Brenner, H.; Park, J.Y.; Kaneva, R.; Batra, J.; Spurdle, A.; Clements, J.; Teixeira, M.R.; Dicks, E.; Lee, A.; Dunning, A.; Baynes, C.; Conroy, D.; Maranian, M.J; Ahmed, S.; Govindasami, K.; Guy, M.; Wilkinson, R.A.; Sawyer, E.J.; Morgan, A.; Dearnaley, D.P.; Horwich, A.; Huddart, R.A.; Khoo, V.S.; Parker, C.C.; Van As, N.; Woodhouse, C.J.; Thompson, A.; Dudderidge, T.; Ogden, C.; Cooper, C.S.; Lophatananon, A.; Cox, A.; Southey, M.C.; Hopper, J.L.; English, D.R.; Aly, M.; Adolfsson, J.; Xu, J.; Zheng, S.L.; Yeager, M.; Kaaks, R.; Diver, W.R.; Gaudet, M.; Stern, A.; Corral, R.; Joshi, A.D.; Shahabi, A.; Wahlfors, T.; Tammela, T.L.J.; Auvinen, A.; Virtamo, J.; Klarskov, P.; Nordestgaard, B.G.; Roder, M.A.; Nielsen, S.F.; Bojesen, S.E.; Siddiq, A.; FitzGerald, L.M.; Kolb, S.; Kwon, E.M.; Karyadi, D.M.; Blot, W.J.; Zheng, W.; Cai, Q.; McDonnell, S.K.; Rinckleb, A.; Drake, B.; Colditz, G.; Wokolorczyk, D.; Stephenson, R.A.; Teerlink, C.; Muller, H.; Rothenbacher, D.; Sellers, T.A.; Lin, H-Y.; Slavov, C.; Mitev, V.; Lose, F.; Srinivasan, S.; Maia, S.; Paulo, P.; Lange, E.; Cooney, K.A.; Vincent, D.; Bacot, F.; Tessier, D.C.; Kote-Jarai, Z.; Easton, D.F.
Contribuinte(s)

The COGS-Cancer Research UK GWAS-ELLIPSE

The PRACTICAL Consortium

The UK ProtecT Study Collaborators

The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons‟ Section of Oncology

The Australian Prostate Cancer Bioresource

The COGS-Cancer Research UK GWAS-ELLIPSE
Data(s)

01/11/2012
Resumo

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10−8). More than 70 prostate cancer susceptibility loci, explaining ~30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
Identificador

http://eprints.qut.edu.au/57027/
Publicador

Nature Publishing Group
Relação

DOI:10.1038/ng.2560

Eeles, R.A., Al Olama , A.A., Benlloch, S., Saunders, E.J., Leongamornlert, D.A., Tymrakiewicz , M., Ghoussaini , M., Luccarini, C., Dennis, J., Jugurnauth-Little, S., Dadaev, T., Neal, D.E., Hamdy, F.C., Donovan, J.L., Muir, K., Giles, G.G., Severi, G., Wiklund, F., Gronberg, H., Haiman , C.A., Schumacher, F., Henderson , B.E., Marchand, L.L, Lindstrom, S., Kraft, P., Hunter, D.J., Gapstur, S., Chanock, S., Berndt, S.I., Albanes, D., Andriole, G., Schleutker, J., Weischer, M., Canzian, F., Riboli, A., Key, T.J., Travis, R.C., Campa, D., Ingles, S.A., John, E.M., Hayes, R.B., Pharoah, P., Pashayan, N., Khaw, K-T., Stanford, J.L., Ostrander, E.A., Signorello, L.B., Thibodeau, S.N., Schaid, D., Maier, C., Vogel, W., Kibel, S.A., Cybulski, C., Lubinski, J., Cannon-Albright, L., Brenner, H., Park, J.Y., Kaneva, R., Batra, J., Spurdle, A., Clements, J., Teixeira, M.R., Dicks, E., Lee, A., Dunning, A., Baynes, C., Conroy, D., Maranian, M.J, Ahmed, S., Govindasami, K., Guy, M., Wilkinson, R.A., Sawyer, E.J., Morgan, A., Dearnaley, D.P., Horwich, A., Huddart, R.A., Khoo, V.S., Parker, C.C., Van As, N., Woodhouse, C.J., Thompson, A., Dudderidge, T., Ogden, C., Cooper, C.S., Lophatananon, A., Cox, A., Southey, M.C., Hopper, J.L., English, D.R., Aly, M., Adolfsson, J., Xu, J., Zheng, S.L., Yeager, M., Kaaks, R., Diver, W.R., Gaudet, M., Stern, A., Corral, R., Joshi, A.D., Shahabi, A., Wahlfors, T., Tammela, T.L.J., Auvinen, A., Virtamo, J., Klarskov, P., Nordestgaard, B.G., Roder, M.A., Nielsen, S.F., Bojesen, S.E., Siddiq, A., FitzGerald, L.M., Kolb, S., Kwon, E.M., Karyadi, D.M., Blot, W.J., Zheng, W., Cai, Q., McDonnell, S.K., Rinckleb, A., Drake, B., Colditz, G., Wokolorczyk, D., Stephenson, R.A., Teerlink, C., Muller, H., Rothenbacher, D., Sellers, T.A., Lin, H-Y., Slavov, C., Mitev, V., Lose, F., Srinivasan, S., Maia, S., Paulo, P., Lange, E., Cooney, K.A., Vincent, D., Bacot, F., Tessier, D.C., Kote-Jarai, Z., & Easton, D.F. (2012) Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping. Nature Genetics, 45(4), pp. 385-391.
Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation
Tipo

Journal Article
Acesso ao item digital