A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Autoria(s): Amin Al Olama, A.; Kote-Jarai, Z.; Schumacher, F.R.; Wiklund, F.; Berndt, S.I.; Benlloch, S.; Giles, G.G.; Severi, G.; Neal, D.E.; Hamdy, F.C.; Donovan, J.L.; Hunter, D.J.; Henderson, B.E.; Thun, M.J.; Gaziano, M.; Giovannucci, E.L.; Siddiq, A.; Travis, R.C.; Cox, D.G.; Canzian, F.; Riboli, E.; Key, T.J.; Andriole, G.; Albanes, D.; Hayes, R.B.; Schleutker, J.; Auvinen, A.; Tammela, T.L.J.; Weischer, M.; Stanford, J.L.; Ostrander, E.A.; Cybulski, C.; Lubinski, J.; Thibodeau, S.N.; Schaid, D.J.; Sorensen, K. D.; Batra, J.; Clements, J.A.; Chambers, S.; Aitken, J.; Gardiner, R.A.; Maier, C.; Vogel, W.; Dork, T.; Brenner, H.; Habuchi, T.; Ingles, S.; John, E.M.; Dickinson, J.L.; Cannon-Albright, L.; Teixeira, M.R.; Kaneva, R.; Zhang, H.-W.; Lu, Y.-J.; Park, J.Y.; Cooney, K.A.; Muir, K.R.; Leongamornlert, D.A.; Saunders, E.; Tymrakiewicz, M.; Mahmud, N.; Guy, M.; Govindasami, K.; O'Brien, L.T.; Wilkinson, R.A.; Hall, A.L.; Sawyer, E.J.; Dadaev, T.; Morrison, J.; Dearnaley, D.P.; Horwich, A.; Huddart, R.A.; Khoo, V.S.; Parker, C.C.; Van As, N.; Woodhouse, C.J.; Thompson, A.; Dudderidge, T.; Ogden, C.; Cooper, C.S.; Lophatonanon, A.; Southey, M.C.; Hopper, J.L.; English, D.; Virtamo, J.; Le Marchand, L.; Campa, D.; Kaaks, R.; Lindstrom, S.; Diver, W.R.; Gapstur, S.; Yeager, M.; Cox, A.; Stern, M.C.; Corral, R.; Aly, M.; Isaacs, W.; Adolfsson, J.; Xu, J.; Zheng, S.L.; Wahlfors, T.; Taari, K.; Kujala, P.; Klarskov, P.; Nordestgaard, B.G.; Roder, M.A.; Frikke-Schmidt, R.; Bojesen, S.E.; FitzGerald, L.M.; Kolb, S.; Kwon, E.M.; Karyadi, D.M.; Orntoft, T.F.; Borre, M.; Rinckleb, A.; Luedeke, M.; Herkommer, K.; Meyer, A.; Serth, J.; Marthick, J.R.; Patterson, B.; Wokolorczyk, D.; Spurdle, A.; Lose, F.; McDonnell, S.K.; Joshi, A.D.; Shahabi, A.; Pinto, P.; Santos, J.; Ray, A.; Sellers, T.A.; Lin, H.-Y.; Stephenson, R.A.; Teerlink, C.; Muller, H.; Rothenbacher, D.; Tsuchiya, N.; Narita, S.; Cao, G.-W.; Slavov, C.; Mitev, V.; Chanock, S.; Gronberg, H.; Haiman, C.A.; Kraft, P.; Easton, D.F.; Eeles, R.A.
Data(s)

2012
Resumo

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.
Identificador

http://eprints.qut.edu.au/56933/
Publicador

Oxford University Press
Relação

DOI:10.1093/hmg/dds425

Amin Al Olama, A., Kote-Jarai, Z., Schumacher, F.R., Wiklund, F., Berndt, S.I., Benlloch, S., Giles, G.G., Severi, G., Neal, D.E., Hamdy, F.C., Donovan, J.L., Hunter, D.J., Henderson, B.E., Thun, M.J., Gaziano, M., Giovannucci, E.L., Siddiq, A., Travis, R.C., Cox, D.G., Canzian, F., Riboli, E., Key, T.J., Andriole, G., Albanes, D., Hayes, R.B., Schleutker, J., Auvinen, A., Tammela, T.L.J., Weischer, M., Stanford, J.L., Ostrander, E.A., Cybulski, C., Lubinski, J., Thibodeau, S.N., Schaid, D.J., Sorensen, K. D., Batra, J., Clements, J.A., Chambers, S., Aitken, J., Gardiner, R.A., Maier, C., Vogel, W., Dork, T., Brenner, H., Habuchi, T., Ingles, S., John, E.M., Dickinson, J.L., Cannon-Albright, L., Teixeira, M.R., Kaneva, R., Zhang, H.-W., Lu, Y.-J., Park, J.Y., Cooney, K.A., Muir, K.R., Leongamornlert, D.A., Saunders, E., Tymrakiewicz, M., Mahmud, N., Guy, M., Govindasami, K., O'Brien, L.T., Wilkinson, R.A., Hall, A.L., Sawyer, E.J., Dadaev, T., Morrison, J., Dearnaley, D.P., Horwich, A., Huddart, R.A., Khoo, V.S., Parker, C.C., Van As, N., Woodhouse, C.J., Thompson, A., Dudderidge, T., Ogden, C., Cooper, C.S., Lophatonanon, A., Southey, M.C., Hopper, J.L., English, D., Virtamo, J., Le Marchand, L., Campa, D., Kaaks, R., Lindstrom, S., Diver, W.R., Gapstur, S., Yeager, M., Cox, A., Stern, M.C., Corral, R., Aly, M., Isaacs, W., Adolfsson, J., Xu, J., Zheng, S.L., Wahlfors, T., Taari, K., Kujala, P., Klarskov, P., Nordestgaard, B.G., Roder, M.A., Frikke-Schmidt, R., Bojesen, S.E., FitzGerald, L.M., Kolb, S., Kwon, E.M., Karyadi, D.M., Orntoft, T.F., Borre, M., Rinckleb, A., Luedeke, M., Herkommer, K., Meyer, A., Serth, J., Marthick, J.R., Patterson, B., Wokolorczyk, D., Spurdle, A., Lose, F., McDonnell, S.K., Joshi, A.D., Shahabi, A., Pinto, P., Santos, J., Ray, A., Sellers, T.A., Lin, H.-Y., Stephenson, R.A., Teerlink, C., Muller, H., Rothenbacher, D., Tsuchiya, N., Narita, S., Cao, G.-W., Slavov, C., Mitev, V., Chanock, S., Gronberg, H., Haiman, C.A., Kraft, P., Easton, D.F., & Eeles, R.A. (2012) A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Human Molecular Genetics, 22(2), pp. 408-415.
Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation
Palavras-Chave #111201 Cancer Cell Biology #111203 Cancer Genetics #Meta-analysis #Genome #prostate cancer #susceptibility #aggressive and non-aggressive
Tipo

Journal Article
Acesso ao item digital