Scaffolds for growth factor delivery as applied to bone tissue engineering
Data(s) |
2012
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Resumo |
There remains a substantial shortfall in treatment of severe skeletal injuries. The current gold standard of autologous bone grafting from the same patient, has many undesirable side effects associated such as donor site morbidity. Tissue engineering seeks to offer a solution to this problem. The primary requirements for tissue engineered scaffolds have already been well established, and many materials, such as polyesters, present themselves as potential candidates for bone defects; they have comparable structural features, but they often lack the required osteoconductivity to promote adequate bone regeneration. By combining these materials with biological growth factors; which promote the infiltration of cells into the scaffold as well as the differentiation into the specific cell and tissue type, it is possible to increase the formation of new bone. However cost and potential complications associated with growth factors means controlled release is an important consideration in the design of new bone tissue engineering strategies. This review will cover recent research in the area of encapsulation and release of growth factors within a variety of different polymeric scaffolds. |
Formato |
application/pdf |
Identificador | |
Publicador |
Hindawi Publishing Corporation |
Relação |
http://eprints.qut.edu.au/55474/1/Manuscript.pdf DOI:10.1155/2012/174942 Blackwood, Keith A., Bock, Nathalie, Dargaville, Tim R., & Woodruff, Maria A. (2012) Scaffolds for growth factor delivery as applied to bone tissue engineering. International Journal of Polymer Science, 2012(174942), pp. 1-25. |
Direitos |
Copyright 2012 The authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Fonte |
Institute of Health and Biomedical Innovation; Science & Engineering Faculty |
Palavras-Chave | #090300 BIOMEDICAL ENGINEERING #090301 Biomaterials #Bone #Growth Factor #Polymers |
Tipo |
Journal Article |