Reconstructing the history of maize streak virus strain a dispersal to reveal diversification hot spots and its origin in southern Africa
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2011
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Resumo |
Maize streak virus strain A (MSV-A), the causal agent of maize streak disease, is today one of the most serious biotic threats to African food security. Determining where MSV-A originated and how it spread transcontinentally could yield valuable insights into its historical emergence as a crop pathogen. Similarly, determining where the major extant MSV-A lineages arose could identify geographical hot spots of MSV evolution. Here, we use model-based phylogeographic analyses of 353 fully sequenced MSV-A isolates to reconstruct a plausible history of MSV-A movements over the past 150 years. We show that since the probable emergence of MSV-A in southern Africa around 1863, the virus spread transcontinentally at an average rate of 32.5 km/year (95% highest probability density interval, 15.6 to 51.6 km/year). Using distinctive patterns of nucleotide variation caused by 20 unique intra-MSV-A recombination events, we tentatively classified the MSV-A isolates into 24 easily discernible lineages. Despite many of these lineages displaying distinct geographical distributions, it is apparent that almost all have emerged within the past 4 decades from either southern or east-central Africa. Collectively, our results suggest that regular analysis of MSV-A genomes within these diversification hot spots could be used to monitor the emergence of future MSV-A lineages that could affect maize cultivation in Africa. © 2011, American Society for Microbiology. |
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Relação |
DOI:10.1128/jvi.00640-11 Monjane, A. L., Harkins, G. W., Martin, D. P., Lemey, P., Lefeuvre, P., Shepherd, D. N., Oluwafemi, S., Simuyandi, M., Zinga, I., Komba, E. K., Lakoutene, D. P., Mandakombo, N., Mboukoulida, J., Semballa, S., Tagne, A., Tiendrébéogo, F., Erdmann, J. B., van Antwerpen, T., Owor, B. E., Flett, B., Ramusi, M., Windram, O. P., Syed, R., Lett, J. M., Briddon, R. W., Markham, P. G., Rybicki, E. P., & Varsani, A. (2011) Reconstructing the history of maize streak virus strain a dispersal to reveal diversification hot spots and its origin in southern Africa. Journal of Virology, 85(18), pp. 9623-9636. |
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Journal Article |