Relationship among CFH and ARMS2 genotypes, macular pigment optical density, and neuroretinal function in persons without age-related macular degeneration


Autoria(s): Feigl, Beatrix; Morris, C. Phillip; Brown, Brian; Zele, Andrew J.
Data(s)

2012

Resumo

Purpose: To determine whether there is a difference in neuroretinal function and in macular pigment optical density between persons with high- and low-risk gene variants for age-related macular degeneration (AMD) and no ophthalmoscopic signs of AMD, and to compare the results on neuroretinal function to patients with manifest early AMD. Methods and Participants: Neuroretinal function was assessed with the multifocal electroretinogram (mfERG) for 32 participants (22 healthy persons with no AMD and 10 early AMD patients). The 22 healthy participants with no AMD had high- or low-risk genotypes for either CFH (rs380390) and/or ARMS2 (rs10490924). Trough-to-peak response densities and peak-implicit times were analyzed in 5 concentric rings. Macular pigment optical densitometry was assessed by customized heterochromatic flicker photometry. Results: Trough-to-peak response densities for concentric rings 1 to 3 were, on average, significantly greater in participants with high-risk genotypes than in participants with low-risk genotypes and in persons with early AMD after correction for age and smoking (p<0.05). The group peak- implicit times for ring 1 were, on average, delayed in the patients with early AMD compared with the participants with high- or low-risk genotypes, although these differences were not significant. There was no significant correlation between genotypes and macular pigment optical density. Conclusion: Increased neuroretinal activity in persons who carry high-risk AMD genotypes may be due to genetically determined subclinical inflammatory and/or histological changes in the retina. Neuroretinal function in healthy persons genetically susceptible to AMD may be a useful additional early biomarker (in combination with genetics) before there is clinical manifestation.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/54760/

Publicador

American Medical Association

Relação

http://eprints.qut.edu.au/54760/1/Feigl%2C_Morris%2C_Brown_and_Zele_Arch_Opth2012_eprints.pdf

DOI:10.1001/archophthalmol.2012.1940

Feigl, Beatrix, Morris, C. Phillip, Brown, Brian, & Zele, Andrew J. (2012) Relationship among CFH and ARMS2 genotypes, macular pigment optical density, and neuroretinal function in persons without age-related macular degeneration. Archives of Ophthalmology, 130(11), pp. 1402-1409.

Direitos

Copyright 2012 American Medical Association. All rights reserved.

Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation; School of Optometry & Vision Science; School of Psychology & Counselling

Palavras-Chave #110906 Sensory Systems #111301 Ophthalmology #111303 Vision Science #Age-related macular degeneration #ARMS2 #CFH #Macular pigment optical density #Neuroretinal function #multifocal electroretiogram
Tipo

Journal Article