Early inflammatory and myogenic responses to resistance exercise in the elderly


Autoria(s): Mathers, Jessica; Farnfield, Michelle; Garnham, Andrew; Caldow, Marissa; Cameron-Smith, David; Peake, Jonathan
Data(s)

30/07/2012

Resumo

Introduction and Methods: This study compared changes in myokine and myogenic genes following resistance exercise (3 sets of 12 repetitions of maximal unilateral knee extension) in 20 elderly men (67.8 ± 1.0 years) and 15 elderly women (67.2 ± 1.5 years). Results: Monocyte chemotactic protein (MCP)-1, macrophage inhibitory protein (MIP)-1β, interleukin (IL)-6 and MyoD mRNA increased significantly (P < 0.05), whereas myogenin and myostatin mRNA decreased significantly after exercise in both groups. Macrophage-1 (Mac-1) and MCP-3 mRNA did not change significantly after exercise in either group. MIP-1β, Mac-1 and myostatin mRNA were significantly higher before and after exercise in men compared with women. In contrast, MCP-3 and myogenin mRNA were significantly higher before and after exercise in the women compared with the men. Conclusions: In elderly individuals, gender influences the mRNA expression of certain myokines and growth factors, both at rest and after resistance exercise. These differences may influence muscle regeneration following muscle injury

Identificador

http://eprints.qut.edu.au/53922/

Publicador

John Wiley & Sons

Relação

DOI:10.1002/mus.23317

Mathers, Jessica, Farnfield, Michelle, Garnham, Andrew, Caldow, Marissa, Cameron-Smith, David, & Peake, Jonathan (2012) Early inflammatory and myogenic responses to resistance exercise in the elderly. Muscle & Nerve, 46(3), pp. 407-412.

Direitos

Copyright 2012 John Wiley & Sons, Inc.

Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation

Palavras-Chave #110308 Geriatrics and Gerontology #110602 Exercise Physiology #exercise #aging #muscle damage #inflammation #oestrogen
Tipo

Journal Article