Expression of PSA-RP2, an alternatively spliced variant from the PSA gene, is increased in prostate cancer tissues but the protein is not secreted from prostate cancer cells
Data(s) |
2010
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Resumo |
PSA-RP2 is a variant transcript expressed from the PSA gene that is conserved in gorillas, chimpanzees and humans suggesting a particular relevance for this transcript in these primates. We demonstrated by qRT-PCR that PSA-RP2 is upregulated in prostate cancer compared with benign prostatic hyperplasia tissues. The PSA-RP2 protein was not detected in seminal fluid and was cytoplasmically localised but not secreted from LNCaP or transfected PC3 prostate cells, despite secretion from transfected Cos-7 and HEK293 kidney cell lines. PSA-RP2-transfected PC3 cells showed slightly decreased proliferation and increased migration towards PC3-conditioned medium that could suggest a functional role in prostate cancer. |
Formato |
application/pdf |
Identificador | |
Publicador |
Walter de Gruyter GmbH and Co. KG |
Relação |
http://eprints.qut.edu.au/43107/1/43107.pdf DOI:10.1515/BC.2010.043 Whitbread, Astrid, Veveris-Lowe, Tara, Dong, Ying, Tan, Olivia, Gardiner, Robert, Samaratunga, Hema, Nicol, David, & Clements, Judith (2010) Expression of PSA-RP2, an alternatively spliced variant from the PSA gene, is increased in prostate cancer tissues but the protein is not secreted from prostate cancer cells. Biological Chemistry: official scientific journal of the GBM, 391(4), pp. 461-466. |
Direitos |
Copyright 2010 Walter de Gruyter The final publication is available at www.degruyter.com |
Fonte |
Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #060100 BIOCHEMISTRY AND CELL BIOLOGY #alternative splicing, biomarker, kallikrein-related peptidase, prostate-specific antigen (PSA) |
Tipo |
Journal Article |