Development of a 3-dimensional human skin equivalent wound model for investigating novel wound healing therapies
Data(s) |
27/09/2010
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Resumo |
Numerous difficulties are associated with the conduct of preclinical studies related to skin and wound repair. Use of small animal models such as rodents is not optimal because of their physiological differences to human skin and mode of wound healing. Although pigs have previously been used because of their human-like mode of healing, the expense and logistics related to their use also renders them suboptimal. In view of this, alternatives are urgently required to advance the field. The experiments reported herein were aimed at developing and validating a simple, reproducible, three-dimensional ex vivo de-epidermised dermis human skin equivalent wound model for the preclinical evaluation of novel wound therapies. Having established that the human skin equivalent wound model does in fact “heal," we tested the effect of two novel wound healing therapies. We also examined the utility of the model for studies exploring the mechanisms underpinning these therapies. Taken together the data demonstrate that these new models will have wide-spread application for the generation of fundamental new information on wound healing processes and also hold potential in facilitating preclinical optimization of dosage, duration of therapies, and treatment strategies prior to clinical trials. |
Formato |
application/pdf |
Identificador | |
Publicador |
Mary Ann Liebert, Inc. Publishers |
Relação |
http://eprints.qut.edu.au/39201/2/Development_of_a_Three-Dimensional_Human_Skin_Equivalent_Wound_Model_for_Investigating_Novel_Wound_Healing_Therapies_TissEng_16_1111-2010.pdf DOI:10.1089/ten.tec.2009.0725 Xie, Yan, Rizzi, Simone, Dawson, Rebecca, Richards, Sean, Leavesley, David, & Upton, Zee (2010) Development of a 3-dimensional human skin equivalent wound model for investigating novel wound healing therapies. Tissue Engineering. Part C. Methods, 16(5), pp. 1111-1123. |
Direitos |
Copyright 2010 Mary Ann Liebert, Inc. Publishers. |
Fonte |
Cell & Molecular Biosciences; Faculty of Science and Technology; Institute of Health and Biomedical Innovation; Science Research Centre |
Palavras-Chave | #060199 Biochemistry and Cell Biology not elsewhere classified #111600 MEDICAL PHYSIOLOGY #119999 Medical and Health Sciences not elsewhere classified #wound healing #skin |
Tipo |
Journal Article |