Persons with age-related maculopathy risk genotypes and clinically normal eyes have reduced mesopic vision


Autoria(s): Feigl, Beatrix; Cao, Dingcai; Morris, Charles P.; Zele, Andrew J.
Data(s)

29/09/2010

Resumo

PURPOSE: To determine if participants with normal visual acuity, no ophthalmoscopically signs of age-related maculopathy (ARM) in both eyes and who are carriers of the CFH, LOC387715 and HRTA1 high-risk genotypes (“gene-positive”) have impaired rod- and cone-mediated mesopic visual function compared to persons who do not carry the risk genotypes (“gene-negative”).---------- METHODS: Fifty-three Caucasian study participants (mean 55.8 ± 6.1) were genotyped for CFH, LOC387715/ARMS2 and HRTA1 polymorphisms. We genotyped single nucleotide polymorphisms (SNPs) in the CFH (rs380390), LOC387715/ARMS2 (rs10490924) and HTRA1 (rs11200638) genes using Applied Biosystems optimised TaqMan assays. We determined the critical fusion frequency (CFF) mediated by cones alone (Long, Middle and Short wavelength sensitive cones; LMS) and by the combined activities of cones and rods (LMSR). The stimuli were generated using a 4-primary photostimulator that provides independent control of the photoreceptor excitation under mesopic light levels. Visual function was further assessed using standard clinical tests, flicker perimetry and microperimetry.---------- RESULTS: The mesopic CFF mediated by rods and cones (LMSR) was significantly reduced in gene-positive compared to gene-negative participants after correction for age (p=0.03). Cone-mediated CFF (LMS) was not significantly different between gene-positive and -negative participants. There were no significant associations between flicker perimetry and microperimetry and genotype.---------- CONCLUSIONS: This is the first study to relate ARM risk genotypes with mesopic visual function in clinically normal persons. These preliminary results could become of clinical importance as mesopic vision may be used to document sub-clinical retinal changes in persons with risk genotypes and to determine whether those persons progress into manifest disease.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/38471/

Publicador

Association for Research in Vision and Ophthalmology

Relação

http://eprints.qut.edu.au/38471/1/38471.pdf

DOI:10.1167/iovs.10-5967

Feigl, Beatrix, Cao, Dingcai, Morris, Charles P., & Zele, Andrew J. (2010) Persons with age-related maculopathy risk genotypes and clinically normal eyes have reduced mesopic vision. Investigative Ophthalmology and Visual Science, 52(1), pp. 1145-1150.

http://purl.org/au-research/grants/ARC/DP1096354

Direitos

Copyright © 2010 by the Association for Research in Vision and Ophthalmology

Fonte

Cell & Molecular Biosciences; Faculty of Health; Faculty of Science and Technology; Institute of Health and Biomedical Innovation; School of Optometry & Vision Science

Palavras-Chave #111399 Optometry and Ophthalmology not elsewhere classified #age-related macular degeneration #genetic diseases #visual field #visual function #mesopic vision
Tipo

Journal Article