Expression of chondromodulin-1 in the temporomandibular joint condylar cartilage and disc
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01/04/2010
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Resumo |
BACKGROUND: The temporomandibular joint (TMJ) cartilage consists of condylar cartilage and disc and undergoes continuous remodeling throughout post-natal life. To maintain the integrity of the TMJ cartilage, anti-angiogenic factors play an important role during the remodeling process. In this study, we investigated the expression of the anti-angiogenic factor, chondromodulin- 1 (ChM-1), in TMJ cartilage and evaluate its potential role in TMJ remodeling. METHODS: Eight TMJ specimens were collected from six 4-month-old Japanese white rabbits. Safranin-O staining was performed to determine proteoglycan content. ChM-1 expression in TMJ condylar cartilage and disc was determined by immunohistochemistry. Three human perforated disc tissue samples were collected for investigation of ChM-1 and vascular endothelial growth factor (VEGF) distribution in perforated TMJ disc. RESULTS: Safranin-O stained weakly in TMJ compared with tibial articular and epiphyseal cartilage. In TMJ, ChM-1 was expressed in the proliferative and hypertrophic zone of condylar cartilage and chondrocyte-like cells in the disc. No expression of ChM-1 was observed in osteoblasts and subchondral bone. ChM-1 and VEGF were both similarly expressed in perforated disc tissues. CONCLUSIONS: ChM-1 may play a role in the regulation of TMJ remodeling by preventing blood vessel invasion of the cartilage, thereby maintaining condylar cartilage and disc integrity. |
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application/pdf |
Identificador | |
Publicador |
Wiley-Blackwell Publishing |
Relação |
http://eprints.qut.edu.au/34400/1/c34400.pdf DOI:10.1111/j.1600-0714.2009.00831.x Fang, Wei, Friis, Thor, Long, Xing, & Xiao, Yin (2010) Expression of chondromodulin-1 in the temporomandibular joint condylar cartilage and disc. Journal Of Oral Pathology & Medicine, 39(4), pp. 356-360. |
Direitos |
Copyright 2010 Wiley-Blackwell Publishing |
Fonte |
Faculty of Built Environment and Engineering; Institute of Health and Biomedical Innovation; School of Engineering Systems |
Palavras-Chave | #060100 BIOCHEMISTRY AND CELL BIOLOGY #110300 CLINICAL SCIENCES #110500 DENTISTRY #chondromodulin-1 #immunohistochemistry #joint remodeling #temporomandibular joint |
Tipo |
Journal Article |