The return of a forgotten polymer : Polycaprolactone in the 21st century
Data(s) |
01/04/2010
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Resumo |
During the resorbable-polymer-boom of the 1970s and 1980s, polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices. Its popularity was soon superseded by faster resorbable polymers which had fewer perceived disadvantages associated with long term degradation (up to 3-4 years) and intracellular resorption pathways; consequently, PCL was almost forgotten for most of two decades. Recently, a resurgence of interest has propelled PCL back into the biomaterials-arena. The superior rheological and viscoelastic properties over many of its aliphatic polyester counterparts renders PCL easy to manufacture and manipulate into a large range of implants and devices. Coupled with relatively inexpensive production routes and FDA approval, this provides a promising platform for the production of longer-term degradable implants which may be manipulated physically, chemically and biologically to possess tailorable degradation kinetics to suit a specific anatomical site. This review will discuss the application of PCL as a biomaterial over the last two decades focusing on the advantages which have propagated its return into the spotlight with a particular focus on medical devices, drug delivery and tissue engineering. |
Formato |
application/pdf |
Identificador | |
Publicador |
Elsevier |
Relação |
http://eprints.qut.edu.au/32270/1/c32270.pdf DOI:10.1016/j.progpolymsci.2010.04.002 Woodruff, Maria A. & Hutmacher, Dietmar W. (2010) The return of a forgotten polymer : Polycaprolactone in the 21st century. Progress in Polymer Science, 35(10), pp. 1217-1256. http://purl.org/au-research/grants/arc/DP0989000 |
Direitos |
Copyright 2010 Elsevier |
Fonte |
Faculty of Built Environment and Engineering; Institute of Health and Biomedical Innovation |
Palavras-Chave | #090301 Biomaterials #polymer #polycaprolactone #biomaterial #resorbable #scaffold |
Tipo |
Journal Article |